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2k27

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==Solution structure of Human Pax8 Paired Box Domain==
==Solution structure of Human Pax8 Paired Box Domain==
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<StructureSection load='2k27' size='340' side='right' caption='[[2k27]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2k27' size='340' side='right'caption='[[2k27]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2k27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K27 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2k27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K27 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PAX8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k27 RCSB], [http://www.ebi.ac.uk/pdbsum/2k27 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k27 OCA], [https://pdbe.org/2k27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k27 RCSB], [https://www.ebi.ac.uk/pdbsum/2k27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k27 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PAX8_HUMAN PAX8_HUMAN]] Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:[http://omim.org/entry/218700 218700]]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.<ref>PMID:9590296</ref> <ref>PMID:11232006</ref> <ref>PMID:11502839</ref>
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[https://www.uniprot.org/uniprot/PAX8_HUMAN PAX8_HUMAN] Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:[https://omim.org/entry/218700 218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.<ref>PMID:9590296</ref> <ref>PMID:11232006</ref> <ref>PMID:11502839</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAX8_HUMAN PAX8_HUMAN]] Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
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[https://www.uniprot.org/uniprot/PAX8_HUMAN PAX8_HUMAN] Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k27_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k27_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k27 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2k27" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boelens, R]]
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[[Category: Large Structures]]
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[[Category: Codutti, L]]
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[[Category: Boelens R]]
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[[Category: Corazza, A]]
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[[Category: Codutti L]]
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[[Category: Esposito, G]]
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[[Category: Corazza A]]
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[[Category: Fogolari, F]]
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[[Category: Esposito G]]
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[[Category: Ingen, H van]]
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[[Category: Fogolari F]]
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[[Category: Quadrifoglio, F]]
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[[Category: Quadrifoglio F]]
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[[Category: Tell, G]]
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[[Category: Tell G]]
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[[Category: Vascotto, C]]
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[[Category: Vascotto C]]
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[[Category: Viglino, P]]
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[[Category: Viglino P]]
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[[Category: 3d nmr]]
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[[Category: Van Ingen H]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Induced fit]]
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[[Category: Nucleus]]
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[[Category: Paired domain]]
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[[Category: Pax8]]
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[[Category: Phosphoprotein]]
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[[Category: Solution structure]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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[[Category: Triple frequency]]
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Current revision

Solution structure of Human Pax8 Paired Box Domain

PDB ID 2k27

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