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2krr
From Proteopedia
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==Solution structure of the RBD1,2 domains from human nucleolin== | ==Solution structure of the RBD1,2 domains from human nucleolin== | ||
| - | <StructureSection load='2krr' size='340' side='right'caption='[[2krr | + | <StructureSection load='2krr' size='340' side='right'caption='[[2krr]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2krr]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2krr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRR FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2krr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krr OCA], [https://pdbe.org/2krr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2krr RCSB], [https://www.ebi.ac.uk/pdbsum/2krr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2krr ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NUCL_HUMAN NUCL_HUMAN] Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.<ref>PMID:10393184</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arumugam | + | [[Category: Arumugam N]] |
| - | [[Category: Bates | + | [[Category: Bates PJ]] |
| - | [[Category: Lane | + | [[Category: Lane AN]] |
| - | [[Category: Maliekal | + | [[Category: Maliekal J]] |
| - | [[Category: Miller | + | [[Category: Miller C]] |
| - | [[Category: Trent | + | [[Category: Trent JO]] |
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Current revision
Solution structure of the RBD1,2 domains from human nucleolin
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Categories: Homo sapiens | Large Structures | Arumugam N | Bates PJ | Lane AN | Maliekal J | Miller C | Trent JO
