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2ve9

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==XRAY STRUCTURE OF KOPS BOUND GAMMA DOMAIN OF FTSK (P. AERUGINOSA)==
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<StructureSection load='2ve9' size='340' side='right' caption='[[2ve9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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==Xray structure of KOPS bound gamma domain of FtsK (P. aeruginosa)==
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<StructureSection load='2ve9' size='340' side='right'caption='[[2ve9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ve9]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VE9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ve9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VE9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2iuu|2iuu]], [[2iut|2iut]], [[2j5o|2j5o]], [[2ve8|2ve8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ve9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ve9 OCA], [http://pdbe.org/2ve9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ve9 RCSB], [http://www.ebi.ac.uk/pdbsum/2ve9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ve9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ve9 OCA], [https://pdbe.org/2ve9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ve9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ve9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ve9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FTSK_PSEAE FTSK_PSEAE]] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (Probable).<ref>PMID:16916635</ref> <ref>PMID:18722176</ref>
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[https://www.uniprot.org/uniprot/FTSK_PSEAE FTSK_PSEAE] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (Probable).<ref>PMID:16916635</ref> <ref>PMID:18722176</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2ve9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2ve9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2ve9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2ve9" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[Tubulin|Tubulin]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Allen, M D]]
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[[Category: Large Structures]]
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[[Category: Lowe, J]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Sherratt, D J]]
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[[Category: Allen MD]]
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[[Category: Atp-binding]]
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[[Category: Lowe J]]
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[[Category: Bacterial cell division]]
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[[Category: Sherratt DJ]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Chromosome partition]]
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[[Category: Dna binding]]
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[[Category: Dna-binding]]
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[[Category: Ftsk]]
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[[Category: Ftsz]]
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[[Category: Inner membrane]]
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[[Category: Membrane]]
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[[Category: Nucleotide-binding]]
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[[Category: Translocase]]
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[[Category: Transmembrane]]
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[[Category: Transport protein]]
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[[Category: Winged helix]]
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Current revision

Xray structure of KOPS bound gamma domain of FtsK (P. aeruginosa)

PDB ID 2ve9

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