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2vm6

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[[Image:2vm6.jpg|left|200px]]<br /><applet load="2vm6" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2vm6, resolution 2.20&Aring;" />
 
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'''HUMAN BCL2-A1 IN COMPLEX WITH BIM-BH3 PEPTIDE'''<br />
 
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==About this Structure==
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==Human Bcl2-A1 in complex with Bim-BH3 peptide==
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2VM6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+1150'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM6 OCA].
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<StructureSection load='2vm6' size='340' side='right'caption='[[2vm6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Protein complex]]
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<table><tr><td colspan='2'>[[2vm6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VM6 FirstGlance]. <br>
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[[Category: Arrowsmith, C.H.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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[[Category: Berg, S.Van.Den.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Berglund, H.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vm6 OCA], [https://pdbe.org/2vm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vm6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vm6 ProSAT]</span></td></tr>
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[[Category: Busam, R.D.]]
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</table>
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[[Category: Collins, R.]]
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== Function ==
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[[Category: Dahlgren, L.G.]]
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[https://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
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[[Category: Edwards, A.M.]]
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== Evolutionary Conservation ==
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[[Category: Flodin, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Flores, A.]]
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Check<jmol>
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[[Category: Graslund, S.]]
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<jmolCheckbox>
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[[Category: Hammarstrom, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/2vm6_consurf.spt"</scriptWhenChecked>
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[[Category: Herman, M.D.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Johansson, I.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Kallas, A.]]
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</jmolCheckbox>
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[[Category: Karlberg, T.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vm6 ConSurf].
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[[Category: Kotenyova, T.]]
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<div style="clear:both"></div>
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[[Category: Lehtio, L.]]
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<div style="background-color:#fffaf0;">
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[[Category: Moche, M.]]
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== Publication Abstract from PubMed ==
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[[Category: Nilsson, M.E.]]
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Evasion of apoptosis is recognized as a characteristic of malignant growth. Anti-apoptotic B-cell lymphoma-2 (Bcl-2) family members have therefore emerged as potential therapeutic targets due to their critical role in proliferating cancer cells. Here, we present the crystal structure of Bfl-1, the last anti-apoptotic Bcl-2 family member to be structurally characterized, in complex with a peptide corresponding to the BH3 region of the pro-apoptotic protein Bim. The structure reveals distinct features at the peptide-binding site, likely to define the binding specificity for pro-apoptotic proteins. Superposition of the Bfl-1:Bim complex with that of Mcl-1:Bim reveals a significant local plasticity of hydrophobic interactions contributed by the Bim peptide, likely to be the basis for the multi specificity of Bim for anti-apoptotic proteins.
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[[Category: Nordlund, P.]]
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[[Category: Nyman, T.]]
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[[Category: Persson, C.]]
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[[Category: Sagemark, J.]]
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[[Category: Sgc, Structural.Genomics.Consortium.]]
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[[Category: Svensson, L.]]
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[[Category: Thorsell, A.G.]]
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[[Category: Tresaugues, L.]]
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[[Category: Weigelt, J.]]
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[[Category: Welin, M.]]
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[[Category: SO4]]
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[[Category: alternative splicing]]
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[[Category: antiapoptotic]]
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[[Category: apoptosis]]
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[[Category: b-cell lymphoma2]]
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[[Category: bcl-2a1]]
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[[Category: bcl2a1]]
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[[Category: bfl-1]]
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[[Category: bim]]
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[[Category: cytoplasm]]
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[[Category: immune system]]
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[[Category: membrane]]
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[[Category: polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 13 08:14:58 2008''
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Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.,Herman MD, Nyman T, Welin M, Lehtio L, Flodin S, Tresaugues L, Kotenyova T, Flores A, Nordlund P FEBS Lett. 2008 Oct 29;582(25-26):3590-4. Epub 2008 Sep 21. PMID:18812174<ref>PMID:18812174</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vm6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund H]]
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[[Category: Busam RD]]
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[[Category: Collins R]]
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[[Category: Dahlgren LG]]
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[[Category: Edwards AM]]
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[[Category: Flodin S]]
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[[Category: Flores A]]
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[[Category: Graslund S]]
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[[Category: Hammarstrom M]]
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[[Category: Herman MD]]
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[[Category: Johansson I]]
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[[Category: Kallas A]]
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[[Category: Karlberg T]]
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[[Category: Kotenyova T]]
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[[Category: Lehtio L]]
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[[Category: Moche M]]
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[[Category: Nilsson ME]]
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[[Category: Nordlund P]]
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[[Category: Nyman T]]
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[[Category: Persson C]]
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[[Category: Sagemark J]]
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[[Category: Svensson L]]
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[[Category: Thorsell AG]]
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[[Category: Tresaugues L]]
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[[Category: Weigelt J]]
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[[Category: Welin M]]
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[[Category: Van den Berg S]]

Current revision

Human Bcl2-A1 in complex with Bim-BH3 peptide

PDB ID 2vm6

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