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2w1j

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[[Image:2w1j.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF SORTASE C-1 (SRTC-1) from Streptococcus pneumoniae==
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The line below this paragraph, containing "STRUCTURE_2w1j", creates the "Structure Box" on the page.
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<StructureSection load='2w1j' size='340' side='right'caption='[[2w1j]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W1J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.24&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2w1j| PDB=2w1j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1j OCA], [https://pdbe.org/2w1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w1j RCSB], [https://www.ebi.ac.uk/pdbsum/2w1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w1j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0H2UNQ9_STRPN A0A0H2UNQ9_STRPN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptococcus pneumoniae is a piliated pathogen whose ability to circumvent vaccination and antibiotic treatment strategies is a cause of mortality worldwide. Pili play important roles in pneumococcal infection, but little is known about their biogenesis mechanism or the relationship between components of the pilus-forming machinery, which includes the fiber pilin (RrgB), two minor pilins (RrgA, RrgC), and three sortases (SrtC-1, SrtC-2, SrtC-3). Here we show that SrtC-1 is the main pilus-polymerizing transpeptidase, and electron microscopy analyses of RrgB fibers reconstituted in vitro reveal that they structurally mimic the pneumococcal pilus backbone. Crystal structures of both SrtC-1 and SrtC-3 reveal active sites whose access is controlled by flexible lids, unlike in non-pilus sortases, and suggest that substrate specificity is dictated by surface recognition coupled to lid opening. The distinct structural features of pilus-forming sortases suggest a common pilus biogenesis mechanism that could be exploited for the development of broad-spectrum antibacterials.
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===CRYSTAL STRUCTURE OF SORTASE C-1 (SRTC-1) FROM STREPTOCOCCUS PNEUMONIAE===
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Sortase-Mediated Pilus Fiber Biogenesis in Streptococcus pneumoniae.,Manzano C, Contreras-Martel C, El Mortaji L, Izore T, Fenel D, Vernet T, Schoehn G, Di Guilmi AM, Dessen A Structure. 2008 Dec 12;16(12):1838-48. PMID:19081060<ref>PMID:19081060</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19081060}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2w1j" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19081060 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19081060}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2w1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1J OCA].
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Contreras-Martel C]]
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==Reference==
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[[Category: Dessen A]]
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<ref group="xtra">PMID:019081060</ref><references group="xtra"/>
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[[Category: Di Guilmi AM]]
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[[Category: Peptidyltransferase]]
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[[Category: El Mortaji L]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Fenel D]]
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[[Category: Contreras-Martel, C.]]
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[[Category: Izore T]]
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[[Category: Dessen, A.]]
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[[Category: Manzano C]]
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[[Category: Fenel, D.]]
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[[Category: Schoehn G]]
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[[Category: Guilmi, A M.Di.]]
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[[Category: Vernet T]]
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[[Category: Izore, T.]]
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[[Category: Manzano, C.]]
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[[Category: Mortaji, L El.]]
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[[Category: Schoehn, G.]]
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[[Category: Vernet, T.]]
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[[Category: Pathogenicity]]
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[[Category: Transferase]]
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Current revision

CRYSTAL STRUCTURE OF SORTASE C-1 (SRTC-1) from Streptococcus pneumoniae

PDB ID 2w1j

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