2w3c

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[[Image:2w3c.jpg|left|200px]]
 
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==Globular head region of the human general vesicular transport factor p115==
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The line below this paragraph, containing "STRUCTURE_2w3c", creates the "Structure Box" on the page.
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<StructureSection load='2w3c' size='340' side='right'caption='[[2w3c]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w3c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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{{STRUCTURE_2w3c| PDB=2w3c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3c OCA], [https://pdbe.org/2w3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3c RCSB], [https://www.ebi.ac.uk/pdbsum/2w3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/USO1_HUMAN USO1_HUMAN] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w3c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The golgin family gives identity and structure to the Golgi apparatus and is part of a complex protein network at the Golgi membrane. The golgin p115 is targeted by the GTPase Rab1a, contains a large globular head region and a long region of coiled-coil which forms an extended rod-like structure. p115 serves as vesicle tethering factor and plays an important role at different steps of vesicular transport. Here we present the 2.2 A-resolution X-ray structure of the globular head region of p115. The structure exhibits an armadillo fold that is decorated by elongated loops and carries a C-terminal non-canonical repeat. This terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering.
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===GLOBULAR HEAD REGION OF THE HUMAN GENERAL VESICULAR TRANSPORT FACTOR P115===
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Unusual armadillo fold in the human general vesicular transport factor p115.,Striegl H, Roske Y, Kummel D, Heinemann U PLoS ONE. 2009;4(2):e4656. Epub 2009 Feb 27. PMID:19247479<ref>PMID:19247479</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2W3C is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3C OCA].
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<div class="pdbe-citations 2w3c" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Heinemann, U.]]
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[[Category: Large Structures]]
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[[Category: Kummel, D.]]
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[[Category: Heinemann U]]
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[[Category: Roske, Y.]]
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[[Category: Kummel D]]
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[[Category: Striegl, H.]]
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[[Category: Roske Y]]
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[[Category: Armadillo fold]]
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[[Category: Striegl H]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Endoplasmatic reticulum]]
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[[Category: Er-golgi transport]]
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[[Category: Golgi]]
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[[Category: Golgi apparatus]]
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[[Category: Golgin]]
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[[Category: Membrane]]
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[[Category: Membrane vesicle tethering]]
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[[Category: P115]]
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[[Category: Transport protein]]
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[[Category: Uso1p]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:32:23 2009''
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Current revision

Globular head region of the human general vesicular transport factor p115

PDB ID 2w3c

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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