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2x35
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2x35' size='340' side='right' caption='[[2x35]], [[Resolution|resolution]] 2.00Å' scene=''> | + | ==Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.== |
| + | <StructureSection load='2x35' size='340' side='right'caption='[[2x35]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2x35]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2x35]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X35 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x35 OCA], [https://pdbe.org/2x35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x35 RCSB], [https://www.ebi.ac.uk/pdbsum/2x35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x35 ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x35_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x35_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x35 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2x35" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Peregrin|Peregrin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Allen | + | [[Category: Large Structures]] |
| - | [[Category: Bonadies | + | [[Category: Allen MD]] |
| - | [[Category: Bycroft | + | [[Category: Bonadies N]] |
| - | [[Category: Freund | + | [[Category: Bycroft M]] |
| - | [[Category: Gottgens | + | [[Category: Freund SMV]] |
| - | [[Category: Huntly | + | [[Category: Gottgens B]] |
| - | [[Category: Kvinlaug | + | [[Category: Huntly BJP]] |
| - | [[Category: Santiveri | + | [[Category: Kvinlaug B]] |
| - | [[Category: Vezzoli | + | [[Category: Santiveri CM]] |
| - | + | [[Category: Vezzoli A]] | |
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Current revision
Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.
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Categories: Homo sapiens | Large Structures | Allen MD | Bonadies N | Bycroft M | Freund SMV | Gottgens B | Huntly BJP | Kvinlaug B | Santiveri CM | Vezzoli A
