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2x3x

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{{Seed}}
 
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[[Image:2x3x.jpg|left|200px]]
 
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==structure of mouse syndapin I (crystal form 1)==
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The line below this paragraph, containing "STRUCTURE_2x3x", creates the "Structure Box" on the page.
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<StructureSection load='2x3x' size='340' side='right'caption='[[2x3x]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2x3x]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X3X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x3x OCA], [https://pdbe.org/2x3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x3x RCSB], [https://www.ebi.ac.uk/pdbsum/2x3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x3x ProSAT]</span></td></tr>
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{{STRUCTURE_2x3x| PDB=2x3x | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PACN1_MOUSE PACN1_MOUSE] May play a role in endocytosis.<ref>PMID:11082044</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x3x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x3x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Members of the Bin/amphiphysin/Rvs (BAR) domain protein superfamily are involved in membrane remodeling in various cellular pathways ranging from endocytic vesicle and T-tubule formation to cell migration and neuromorphogenesis. Membrane curvature induction and stabilization are encoded within the BAR or Fer-CIP4 homology-BAR (F-BAR) domains, alpha-helical coiled coils that dimerize into membrane-binding modules. BAR/F-BAR domain proteins often contain an SH3 domain, which recruits binding partners such as the oligomeric membrane-fissioning GTPase dynamin. How precisely BAR/F-BAR domain-mediated membrane deformation is regulated at the cellular level is unknown. Here we present the crystal structures of full-length syndapin 1 and its F-BAR domain. Our data show that syndapin 1 F-BAR-mediated membrane deformation is subject to autoinhibition by its SH3 domain. Release from the clamped conformation is driven by association of syndapin 1 SH3 with the proline-rich domain of dynamin 1, thereby unlocking its potent membrane-bending activity. We hypothesize that this mechanism might be commonly used to regulate BAR/F-BAR domain-induced membrane deformation and to potentially couple this process to dynamin-mediated fission. Our data thus suggest a structure-based model for SH3-mediated regulation of BAR/F-BAR domain function.
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===STRUCTURE OF MOUSE SYNDAPIN I (CRYSTAL FORM 1)===
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Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation.,Rao Y, Ma Q, Vahedi-Faridi A, Sundborger A, Pechstein A, Puchkov D, Luo L, Shupliakov O, Saenger W, Haucke V Proc Natl Acad Sci U S A. 2010 Apr 19. PMID:20404169<ref>PMID:20404169</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2X3X is a 5 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X3X OCA].
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<div class="pdbe-citations 2x3x" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Haucke, V.]]
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[[Category: Haucke V]]
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[[Category: Ma, Q.]]
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[[Category: Ma Q]]
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[[Category: Rao, Y.]]
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[[Category: Rao Y]]
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[[Category: Saenger, W.]]
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[[Category: Saenger W]]
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[[Category: Vahedi-Faridi, A.]]
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[[Category: Vahedi-Faridi A]]
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[[Category: Bar]]
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[[Category: Dynamin]]
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[[Category: Endocytosis]]
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[[Category: N-wasp]]
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[[Category: Pacsin i]]
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[[Category: Phosphoprotein]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:43:26 2010''
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Current revision

structure of mouse syndapin I (crystal form 1)

PDB ID 2x3x

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