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2x8a

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<StructureSection load='2x8a' size='340' side='right'caption='[[2x8a]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2x8a' size='340' side='right'caption='[[2x8a]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X8A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8a OCA], [http://pdbe.org/2x8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8a RCSB], [http://www.ebi.ac.uk/pdbsum/2x8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8a ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8a OCA], [https://pdbe.org/2x8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8a RCSB], [https://www.ebi.ac.uk/pdbsum/2x8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8a ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NVL_HUMAN NVL_HUMAN] Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).<ref>PMID:15469983</ref> <ref>PMID:16782053</ref> <ref>PMID:22226966</ref> <ref>PMID:26166824</ref> <ref>PMID:26456651</ref> <ref>PMID:28416111</ref> <ref>PMID:29107693</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x8a ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x8a ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund, H]]
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[[Category: Berglund H]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Collins, R]]
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[[Category: Collins R]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Flodin, S]]
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[[Category: Flodin S]]
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[[Category: Flores, A]]
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[[Category: Flores A]]
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[[Category: Graslund, S]]
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[[Category: Graslund S]]
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[[Category: Hammarstrom, M]]
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[[Category: Hammarstrom M]]
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[[Category: Johansson, I]]
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[[Category: Johansson I]]
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[[Category: Kallas, A]]
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[[Category: Kallas A]]
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[[Category: Karlberg, T]]
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[[Category: Karlberg T]]
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[[Category: Kotenyova, T]]
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[[Category: Kotenyova T]]
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[[Category: Kraulis, P]]
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[[Category: Kraulis P]]
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[[Category: Moche, M]]
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[[Category: Moche M]]
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[[Category: Nordlund, P]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T]]
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[[Category: Nyman T]]
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[[Category: Persson, C]]
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[[Category: Persson C]]
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[[Category: Schuetz, P]]
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[[Category: Schuetz P]]
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[[Category: Schuler, H]]
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[[Category: Schuler H]]
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[[Category: Sehic, A]]
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[[Category: Sehic A]]
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[[Category: Siponen, M I]]
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[[Category: Siponen MI]]
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[[Category: Svensson, L]]
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[[Category: Svensson L]]
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[[Category: Thorsell, A G]]
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[[Category: Thorsell AG]]
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[[Category: Tresaugues, L]]
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[[Category: Tresaugues L]]
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[[Category: VanDenBerg, S]]
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[[Category: VanDenBerg S]]
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[[Category: Wahlberg, E]]
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[[Category: Wahlberg E]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Welin, M]]
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[[Category: Welin M]]
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[[Category: Wisniewska, M]]
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[[Category: Wisniewska M]]
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[[Category: Nuclear protein]]
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Current revision

Human Nuclear Valosin containing protein Like (NVL), C-terminal AAA- ATPase domain

PDB ID 2x8a

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