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3zys

From Proteopedia

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[[Image:3zys.png|left|200px]]
 
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==Human dynamin 1 deltaPRD polymer stabilized with GMPPCP==
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The line below this paragraph, containing "STRUCTURE_3zys", creates the "Structure Box" on the page.
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<SX load='3zys' size='340' side='right' viewer='molstar' caption='[[3zys]], [[Resolution|resolution]] 12.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zys]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zys OCA], [https://pdbe.org/3zys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zys RCSB], [https://www.ebi.ac.uk/pdbsum/3zys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zys ProSAT]</span></td></tr>
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{{STRUCTURE_3zys| PDB=3zys | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of clathrin-coated pits, but the specific structural interactions and conformational changes that drive this process remain a mystery. We present the GMPPCP-bound structures of the truncated human dynamin 1 helical polymer at 12.2 A and a fusion protein, GG, linking human dynamin 1's catalytic G domain to its GTPase effector domain (GED) at 2.2 A. The structures reveal the position and connectivity of dynamin fragments in the assembled structure, showing that G domain dimers only form between tetramers in sequential rungs of the dynamin helix. Using chemical crosslinking, we demonstrate that dynamin tetramers are made of two dimers, in which the G domain of one molecule interacts in trans with the GED of another. Structural comparison of GG(GMPPCP) to the GG transition-state complex identifies a hydrolysis-dependent powerstroke that may play a role in membrane-remodeling events necessary for fission.
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===Human dynamin 1 deltaPRD polymer stabilized with GMPPCP===
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A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke.,Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F Cell. 2011 Sep 30;147(1):209-22. PMID:21962517<ref>PMID:21962517</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zys" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21962517}}, adds the Publication Abstract to the page
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21962517 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21962517}}
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__TOC__
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</SX>
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==About this Structure==
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[[3zys]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYS OCA].
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==Reference==
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<ref group="xtra">PMID:021962517</ref><references group="xtra"/>
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[[Category: Dynamin GTPase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chappie, J S.]]
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[[Category: Large Structures]]
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[[Category: Dyda, F.]]
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[[Category: Chappie JS]]
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[[Category: Fang, S.]]
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[[Category: Dyda F]]
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[[Category: Hinshaw, J E.]]
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[[Category: Fang S]]
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[[Category: Leonard, M.]]
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[[Category: Hinshaw JE]]
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[[Category: Mears, J A.]]
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[[Category: Leonard M]]
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[[Category: Milligan, R A.]]
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[[Category: Mears JA]]
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[[Category: Schmid, S L.]]
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[[Category: Milligan RA]]
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[[Category: Endocytosis]]
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[[Category: Schmid SL]]
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[[Category: Gtp hydrolysis]]
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[[Category: Hydrolase-gtp-binding protein complex]]
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[[Category: Membrane remodeling]]
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Current revision

Human dynamin 1 deltaPRD polymer stabilized with GMPPCP

3zys, resolution 12.20Å

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