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4bbq
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==Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11)== | ==Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11)== | ||
| - | <StructureSection load='4bbq' size='340' side='right' caption='[[4bbq]], [[Resolution|resolution]] 2.24Å' scene=''> | + | <StructureSection load='4bbq' size='340' side='right'caption='[[4bbq]], [[Resolution|resolution]] 2.24Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4bbq]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4bbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BBQ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbq OCA], [https://pdbe.org/4bbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bbq RCSB], [https://www.ebi.ac.uk/pdbsum/4bbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbq ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KDM2A_HUMAN KDM2A_HUMAN] Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.<ref>PMID:16362057</ref> <ref>PMID:19001877</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Allerston | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Allerston CK]] |
| - | [[Category: Ball | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Ball L]] |
| - | [[Category: Chen | + | [[Category: Bountra C]] |
| - | + | [[Category: Chen Y]] | |
| - | [[Category: Edlich | + | [[Category: Edlich C]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi O]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Laue | + | [[Category: Laue ED]] |
| - | [[Category: Li | + | [[Category: Li B]] |
| - | [[Category: Watson | + | [[Category: Watson AA]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
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Current revision
Crystal structure of the CXXC and PHD domain of Human Lysine-specific Demethylase 2A (KDM2A)(FBXL11)
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Categories: Homo sapiens | Large Structures | Allerston CK | Arrowsmith CH | Ball L | Bountra C | Chen Y | Edlich C | Edwards A | Gileadi O | Krojer T | Laue ED | Li B | Watson AA | Von Delft F
