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4c2z

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==Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound==
==Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound==
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<StructureSection load='4c2z' size='340' side='right' caption='[[4c2z]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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<StructureSection load='4c2z' size='340' side='right'caption='[[4c2z]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c2z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C2Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c2z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=646:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>646</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c2x|4c2x]], [[4c2y|4c2y]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=646:2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>646</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2z OCA], [https://pdbe.org/4c2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2z RCSB], [https://www.ebi.ac.uk/pdbsum/4c2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2z OCA], [http://pdbe.org/4c2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c2z RCSB], [http://www.ebi.ac.uk/pdbsum/4c2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
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[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Brannigan, J A]]
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[[Category: Large Structures]]
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[[Category: Brassat, U]]
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[[Category: Brannigan JA]]
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[[Category: Heal, W P]]
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[[Category: Brassat U]]
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[[Category: Mann, D J]]
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[[Category: Heal WP]]
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[[Category: Serwa, R A]]
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[[Category: Mann DJ]]
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[[Category: Tate, E W]]
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[[Category: Serwa RA]]
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[[Category: Thinon, E]]
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[[Category: Tate EW]]
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[[Category: Wilkinson, A J]]
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[[Category: Thinon E]]
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[[Category: Wright, M H]]
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[[Category: Wilkinson AJ]]
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[[Category: Myristoylation]]
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[[Category: Wright MH]]
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[[Category: Transferase]]
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Current revision

Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound

PDB ID 4c2z

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