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4c7j
From Proteopedia
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==11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor== | ==11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor== | ||
| - | <StructureSection load='4c7j' size='340' side='right' caption='[[4c7j]], [[Resolution|resolution]] 2.16Å' scene=''> | + | <StructureSection load='4c7j' size='340' side='right'caption='[[4c7j]], [[Resolution|resolution]] 2.16Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4c7j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7J OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4c7j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C7J FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4YQ:4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5-CARBOXAMIDE'>4YQ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4YQ:4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5-CARBOXAMIDE'>4YQ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7j OCA], [https://pdbe.org/4c7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c7j RCSB], [https://www.ebi.ac.uk/pdbsum/4c7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c7j ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]] | + | *[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Boyd S]] |
| - | [[Category: | + | [[Category: Dossetter AG]] |
| - | [[Category: | + | [[Category: Goldberg FW]] |
| - | [[Category: | + | [[Category: Groombridge SD]] |
| - | [[Category: Kemmitt | + | [[Category: Kemmitt PD]] |
| - | [[Category: | + | [[Category: Morentin Gutierrez P]] |
| - | [[Category: | + | [[Category: Robb GR]] |
| - | [[Category: Scott | + | [[Category: Scott JS]] |
| - | [[Category: Sjogren | + | [[Category: Sjogren T]] |
| - | [[Category: Swales | + | [[Category: Swales JG]] |
| - | [[Category: Turnbull | + | [[Category: Turnbull AV]] |
| - | [[Category: Wild | + | [[Category: Wild MJ]] |
| - | [[Category: | + | [[Category: De Schoolmeester J]] |
| - | + | ||
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Current revision
11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor
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