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4cb8

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==Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha==
==Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha==
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<StructureSection load='4cb8' size='340' side='right' caption='[[4cb8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='4cb8' size='340' side='right'caption='[[4cb8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cb8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CB8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cb8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CB8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cb9|4cb9]], [[4cba|4cba]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cb8 RCSB], [http://www.ebi.ac.uk/pdbsum/4cb8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb8 OCA], [https://pdbe.org/4cb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cb8 RCSB], [https://www.ebi.ac.uk/pdbsum/4cb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
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[https://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4cb8" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Ganesh, K]]
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[[Category: Large Structures]]
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[[Category: Johnson, C M]]
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[[Category: Ganesh K]]
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[[Category: Neuberger, M S]]
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[[Category: Johnson CM]]
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[[Category: Rada, C]]
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[[Category: Neuberger MS]]
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[[Category: Simpson, P]]
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[[Category: Rada C]]
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[[Category: Telerman, S B]]
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[[Category: Simpson P]]
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[[Category: Williams, R L]]
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[[Category: Telerman SB]]
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[[Category: VanMaldegem, F]]
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[[Category: Williams RL]]
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[[Category: Aid]]
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[[Category: VanMaldegem F]]
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[[Category: Apoptosis]]
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[[Category: Deaminase]]
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[[Category: Import]]
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Current revision

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha

PDB ID 4cb8

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