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4cbf
From Proteopedia
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==Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus== | ==Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus== | ||
| - | < | + | <SX load='4cbf' size='340' side='right' viewer='molstar' caption='[[4cbf]], [[Resolution|resolution]] 4.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cbf]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4cbf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CBF FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbf OCA], [https://pdbe.org/4cbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cbf RCSB], [https://www.ebi.ac.uk/pdbsum/4cbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cbf ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/E0WXI2_9FLAV E0WXI2_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Dengue virus 2]] | [[Category: Dengue virus 2]] | ||
| + | [[Category: Dengue virus 4]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chew | + | [[Category: Chew PL]] |
| - | [[Category: Kostyuchenko | + | [[Category: Kostyuchenko VA]] |
| - | [[Category: Lok | + | [[Category: Lok SM]] |
| - | [[Category: Ng | + | [[Category: Ng TS]] |
| - | + | ||
| - | + | ||
Current revision
Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus
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