4cmz
From Proteopedia
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==An intertwined homodimer of the PDZ homology domain of periaxin== | ==An intertwined homodimer of the PDZ homology domain of periaxin== | ||
| - | <StructureSection load='4cmz' size='340' side='right' caption='[[4cmz]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='4cmz' size='340' side='right'caption='[[4cmz]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cmz]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4cmz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CMZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmz OCA], [https://pdbe.org/4cmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cmz RCSB], [https://www.ebi.ac.uk/pdbsum/4cmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cmz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PRAX_HUMAN PRAX_HUMAN] Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease type 4F. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PRAX_HUMAN PRAX_HUMAN] Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4cmz" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Han H]] |
| - | [[Category: | + | [[Category: Kursula P]] |
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Current revision
An intertwined homodimer of the PDZ homology domain of periaxin
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