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4cmz

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==An intertwined homodimer of the PDZ homology domain of periaxin==
==An intertwined homodimer of the PDZ homology domain of periaxin==
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<StructureSection load='4cmz' size='340' side='right' caption='[[4cmz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4cmz' size='340' side='right'caption='[[4cmz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cmz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CMZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cmz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CMZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmz OCA], [http://pdbe.org/4cmz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cmz RCSB], [http://www.ebi.ac.uk/pdbsum/4cmz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cmz ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cmz OCA], [https://pdbe.org/4cmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cmz RCSB], [https://www.ebi.ac.uk/pdbsum/4cmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cmz ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PRAX_HUMAN PRAX_HUMAN]] Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease type 4F. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PRAX_HUMAN PRAX_HUMAN] Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease type 4F. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRAX_HUMAN PRAX_HUMAN]] Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.
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[https://www.uniprot.org/uniprot/PRAX_HUMAN PRAX_HUMAN] Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Han, H]]
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[[Category: Large Structures]]
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[[Category: Kursula, P]]
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[[Category: Han H]]
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[[Category: Cell cycle]]
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[[Category: Kursula P]]
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[[Category: Domain swapping]]
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[[Category: Intertwining]]
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Current revision

An intertwined homodimer of the PDZ homology domain of periaxin

PDB ID 4cmz

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