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4cyq

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==Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 45).==
==Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 45).==
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<StructureSection load='4cyq' size='340' side='right' caption='[[4cyq]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='4cyq' size='340' side='right'caption='[[4cyq]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cyq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CYQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cyq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=YAU:N-{2-CHLORO-5-[(3S,4R)-1-[(3R)-4-(4-CHLOROPHENYL)-3-HYDROXYBUTANOYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-YL]PHENYL}-2-(4-FLUOROPHENYL)ACETAMIDE'>YAU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cyn|4cyn]], [[4cyo|4cyo]], [[4cyp|4cyp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=YAU:N-{2-CHLORO-5-[(3S,4R)-1-[(3R)-4-(4-CHLOROPHENYL)-3-HYDROXYBUTANOYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-YL]PHENYL}-2-(4-FLUOROPHENYL)ACETAMIDE'>YAU</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyq OCA], [https://pdbe.org/4cyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyq RCSB], [https://www.ebi.ac.uk/pdbsum/4cyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cyq RCSB], [http://www.ebi.ac.uk/pdbsum/4cyq PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4cyq" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Large Structures]]
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[[Category: Bell, A S.]]
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[[Category: Leishmania major]]
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[[Category: Brannigan, J A.]]
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[[Category: Bell AS]]
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[[Category: Goncalves, V.]]
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[[Category: Brannigan JA]]
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[[Category: Hutton, J A.]]
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[[Category: Goncalves V]]
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[[Category: Leatherbarrow, R J.]]
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[[Category: Hutton JA]]
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[[Category: Paape, D.]]
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[[Category: Leatherbarrow RJ]]
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[[Category: Roberts, S M.]]
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[[Category: Paape D]]
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[[Category: Smith, D F.]]
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[[Category: Roberts SM]]
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[[Category: Tate, E W.]]
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[[Category: Smith DF]]
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[[Category: Waugh, T.]]
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[[Category: Tate EW]]
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[[Category: Wilkinson, A J.]]
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[[Category: Waugh T]]
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[[Category: Drug design]]
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[[Category: Wilkinson AJ]]
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[[Category: Inhibitor]]
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[[Category: Myristoylation]]
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[[Category: Transferase]]
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Current revision

Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 45).

PDB ID 4cyq

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