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4d19

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==Crystal structure of cofactor-free urate oxidase in complex with its 5-peroxoisourate intermediate (X-ray dose, 1.75 MGy)==
==Crystal structure of cofactor-free urate oxidase in complex with its 5-peroxoisourate intermediate (X-ray dose, 1.75 MGy)==
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<StructureSection load='4d19' size='340' side='right' caption='[[4d19]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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<StructureSection load='4d19' size='340' side='right'caption='[[4d19]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d19]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D19 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D19 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IUP:5-(HYDRO)PEROXOISOURATE'>IUP</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d12|4d12]], [[4d13|4d13]], [[4d17|4d17]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUP:5-(HYDRO)PEROXOISOURATE'>IUP</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d19 OCA], [https://pdbe.org/4d19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d19 RCSB], [https://www.ebi.ac.uk/pdbsum/4d19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d19 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d19 OCA], [http://pdbe.org/4d19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d19 RCSB], [http://www.ebi.ac.uk/pdbsum/4d19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d19 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
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[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Urate Oxidase|Urate Oxidase]]
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*[[Urate oxidase 3D structures|Urate oxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Factor independent urate hydroxylase]]
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[[Category: Aspergillus flavus]]
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[[Category: Bui, S]]
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[[Category: Large Structures]]
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[[Category: Steiner, R A]]
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[[Category: Bui S]]
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[[Category: Cofactor-free oxidase]]
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[[Category: Steiner RA]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of cofactor-free urate oxidase in complex with its 5-peroxoisourate intermediate (X-ray dose, 1.75 MGy)

PDB ID 4d19

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