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4ufz
From Proteopedia
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==Synthesis of Novel NAD Dependant DNA Ligase Inhibitors via Negishi Cross-Coupling: Development of SAR and Resistance Studies== | ==Synthesis of Novel NAD Dependant DNA Ligase Inhibitors via Negishi Cross-Coupling: Development of SAR and Resistance Studies== | ||
| - | <StructureSection load='4ufz' size='340' side='right' caption='[[4ufz]], [[Resolution|resolution]] 2.33Å' scene=''> | + | <StructureSection load='4ufz' size='340' side='right'caption='[[4ufz]], [[Resolution|resolution]] 2.33Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ufz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UFZ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4ufz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UFZ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IA7:5,7-BIS(AZANYL)-2-TERT-BUTYL-4-(1,3-THIAZOL-2-YL)PYRIDO[2,3-D]PYRIMIDINE-6-CARBONITRILE'>IA7</scene>, <scene name='pdbligand=IWH:1-(2,4-DIMETHYLBENZYL)-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>IWH</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IA7:5,7-BIS(AZANYL)-2-TERT-BUTYL-4-(1,3-THIAZOL-2-YL)PYRIDO[2,3-D]PYRIMIDINE-6-CARBONITRILE'>IA7</scene>, <scene name='pdbligand=IWH:1-(2,4-DIMETHYLBENZYL)-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>IWH</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ufz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ufz OCA], [https://pdbe.org/4ufz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ufz RCSB], [https://www.ebi.ac.uk/pdbsum/4ufz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ufz ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DNLJ_HAEIN DNLJ_HAEIN] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[DNA ligase|DNA ligase]] | + | *[[DNA ligase 3D structures|DNA ligase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Boriack-Sjodin | + | [[Category: Haemophilus influenzae]] |
| - | [[Category: Carcanague | + | [[Category: Large Structures]] |
| - | [[Category: Gingipali | + | [[Category: Boriack-Sjodin PA]] |
| - | [[Category: Gowravaram | + | [[Category: Carcanague D]] |
| - | [[Category: Hale | + | [[Category: Gingipali L]] |
| - | [[Category: Harang | + | [[Category: Gowravaram M]] |
| - | [[Category: Ioannidis | + | [[Category: Hale M]] |
| - | [[Category: Jahic | + | [[Category: Harang J]] |
| - | [[Category: Johnstone | + | [[Category: Ioannidis G]] |
| - | [[Category: Kutschke | + | [[Category: Jahic H]] |
| - | [[Category: Laganas | + | [[Category: Johnstone M]] |
| - | [[Category: Loch | + | [[Category: Kutschke A]] |
| - | [[Category: Martinez-Botella | + | [[Category: Laganas VA]] |
| - | [[Category: Murphy-Benenato | + | [[Category: Loch J]] |
| - | [[Category: Oguto | + | [[Category: Martinez-Botella G]] |
| - | [[Category: Patel | + | [[Category: Murphy-Benenato KE]] |
| - | + | [[Category: Oguto H]] | |
| + | [[Category: Patel SJ]] | ||
Current revision
Synthesis of Novel NAD Dependant DNA Ligase Inhibitors via Negishi Cross-Coupling: Development of SAR and Resistance Studies
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