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4utq

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(New page: ==A structural model of the active ribosome-bound membrane protein insertase YidC== <StructureSection load='4utq' size='340' side='right' caption='4utq, resolution 8.00&...)
Current revision (11:23, 9 May 2024) (edit) (undo)
 
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==A structural model of the active ribosome-bound membrane protein insertase YidC==
==A structural model of the active ribosome-bound membrane protein insertase YidC==
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<StructureSection load='4utq' size='340' side='right' caption='[[4utq]], [[Resolution|resolution]] 8.00&Aring;' scene=''>
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<SX load='4utq' size='340' side='right' viewer='molstar' caption='[[4utq]], [[Resolution|resolution]] 8.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4utq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UTQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4utq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UTQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4utq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4utq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4utq RCSB], [http://www.ebi.ac.uk/pdbsum/4utq PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8&#8491;</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4utq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4utq OCA], [https://pdbe.org/4utq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4utq RCSB], [https://www.ebi.ac.uk/pdbsum/4utq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4utq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YIDC_ECOLI YIDC_ECOLI] Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F(0)ATP synthase, FtsQ and SecE proteins and for Sec-independent subunit c of the F(0)ATP synthase, M13 phage procoat and the N-terminus of leader peptidase Lep. Probably interacts directly with Sec-independent substrates. Sec-dependent protein FtsQ interacts first with SecY then subsequently with YidC. Sec-dependent LacY and MalF require YidC to acquire tertiary structure and stability, a chaperone-like function, but not for membrane insertion. Stable maltose transport copmplex formation (MalFGK(2)) also requires YidC. Partially complements a Streptococcus mutans yidC2 disruption mutant.<ref>PMID:10675323</ref> <ref>PMID:10949305</ref> <ref>PMID:12724529</ref> <ref>PMID:12950181</ref> <ref>PMID:15140892</ref> <ref>PMID:15067017</ref> <ref>PMID:17073462</ref> <ref>PMID:18456666</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4utq" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[ATPase 3D structures|ATPase 3D structures]]
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*[[Insertase|Insertase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Andreani, J.]]
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[[Category: Large Structures]]
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[[Category: Beckmann, R.]]
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[[Category: Andreani J]]
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[[Category: Berninghausen, O.]]
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[[Category: Beckmann R]]
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[[Category: Bischoff, L.]]
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[[Category: Berninghausen O]]
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[[Category: Schulten, K.]]
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[[Category: Bischoff L]]
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[[Category: Seemayer, S.]]
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[[Category: Schulten K]]
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[[Category: Singharoy, A.]]
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[[Category: Seemayer S]]
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[[Category: Soeding, J.]]
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[[Category: Singharoy A]]
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[[Category: Wickles, S.]]
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[[Category: Soeding J]]
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[[Category: VanderSluis, E O.]]
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[[Category: Wickles S]]
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[[Category: Bioinformatic]]
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[[Category: VanderSluis EO]]
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[[Category: Md simulation]]
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[[Category: Membrane]]
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[[Category: Protein translocation]]
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[[Category: Protein transport]]
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Current revision

A structural model of the active ribosome-bound membrane protein insertase YidC

4utq, resolution 8.00Å

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