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4uxo

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==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
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<StructureSection load='4uxo' size='340' side='right' caption='[[4uxo]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
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<SX load='4uxo' size='340' side='right' viewer='molstar' caption='[[4uxo]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uxo]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uxo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UXO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.3&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uxp|4uxp]], [[4uxr|4uxr]], [[4uxs|4uxs]], [[4uxt|4uxt]], [[4uxy|4uxy]], [[4uy0|4uy0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uxo RCSB], [http://www.ebi.ac.uk/pdbsum/4uxo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxo OCA], [https://pdbe.org/4uxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uxo RCSB], [https://www.ebi.ac.uk/pdbsum/4uxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxo ProSAT]</span></td></tr>
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<table>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Autosomal dominant nonsyndromic intellectual disability;Hereditary sensory and autonomic neuropathy type 2;Autosomal recessive spastic paraplegia type 30. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21487076</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21820098</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21376300</ref>
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== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/KIF1A_HUMAN KIF1A_HUMAN]] Motor for anterograde axonal transport of synaptic vesicle precursors (By similarity). [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
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[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4uxo" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Atherton, J.]]
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[[Category: Large Structures]]
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[[Category: Farabella, I.]]
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[[Category: Atherton J]]
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[[Category: Houdusse, A.]]
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[[Category: Farabella I]]
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[[Category: Moores, C.]]
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[[Category: Houdusse A]]
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[[Category: Rosenfeld, S S.]]
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[[Category: Moores C]]
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[[Category: Topf, M.]]
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[[Category: Rosenfeld SS]]
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[[Category: Yu, I M.]]
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[[Category: Topf M]]
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[[Category: Cryo-em]]
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[[Category: Yu IM]]
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[[Category: Kinesin]]
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[[Category: Microtubule]]
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[[Category: Transport protein]]
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Current revision

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

4uxo, resolution 6.30Å

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