This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4wag

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:27, 9 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Phosphatidylinositol 4-kinase III beta crystallized with MI103 inhibitor==
==Phosphatidylinositol 4-kinase III beta crystallized with MI103 inhibitor==
-
<StructureSection load='4wag' size='340' side='right' caption='[[4wag]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
+
<StructureSection load='4wag' size='340' side='right'caption='[[4wag]], [[Resolution|resolution]] 3.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4wag]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WAG FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4wag]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WAG FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3K7:6-CHLORO-3-(3,4-DIMETHOXYPHENYL)-2-METHYLIMIDAZO[1,2-B]PYRIDAZIN-8-AMINE'>3K7</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.407&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3K7:6-CHLORO-3-(3,4-DIMETHOXYPHENYL)-2-METHYLIMIDAZO[1,2-B]PYRIDAZIN-8-AMINE'>3K7</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wag OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wag RCSB], [http://www.ebi.ac.uk/pdbsum/4wag PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wag OCA], [https://pdbe.org/4wag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wag RCSB], [https://www.ebi.ac.uk/pdbsum/4wag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wag ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PI4KB_HUMAN PI4KB_HUMAN]] Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).<ref>PMID:9405935</ref> <ref>PMID:10559940</ref> <ref>PMID:12749687</ref>
+
[https://www.uniprot.org/uniprot/PI4KB_HUMAN PI4KB_HUMAN] Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).<ref>PMID:9405935</ref> <ref>PMID:10559940</ref> <ref>PMID:12749687</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4wag" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: 1-phosphatidylinositol 4-kinase]]
+
[[Category: Homo sapiens]]
-
[[Category: Boura, E]]
+
[[Category: Large Structures]]
-
[[Category: Chalupska, D]]
+
[[Category: Boura E]]
-
[[Category: Inhibitor]]
+
[[Category: Chalupska D]]
-
[[Category: Transferase]]
+

Current revision

Phosphatidylinositol 4-kinase III beta crystallized with MI103 inhibitor

PDB ID 4wag

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wag"
Personal tools