4wau

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==Crystal structure of CENP-M solved by native-SAD phasing==
==Crystal structure of CENP-M solved by native-SAD phasing==
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<StructureSection load='4wau' size='340' side='right' caption='[[4wau]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4wau' size='340' side='right'caption='[[4wau]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wau]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WAU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wau]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WAU FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p0t|4p0t]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wau OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wau RCSB], [http://www.ebi.ac.uk/pdbsum/4wau PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wau OCA], [https://pdbe.org/4wau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wau RCSB], [https://www.ebi.ac.uk/pdbsum/4wau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wau ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CENPM_HUMAN CENPM_HUMAN] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.<ref>PMID:16716197</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We describe a data collection method that uses a single crystal to solve X-ray structures by native SAD (single-wavelength anomalous diffraction). We solved the structures of 11 real-life examples, including a human membrane protein, a protein-DNA complex and a 266-kDa multiprotein-ligand complex, using this method. The data collection strategy is suitable for routine structure determination and can be implemented at most macromolecular crystallography synchrotron beamlines.
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Fast native-SAD phasing for routine macromolecular structure determination.,Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota AE, Surana P, Kottur J, Nair DT, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang B, Steinmetz MO, Caffrey M, Wang M Nat Methods. 2014 Dec 15. doi: 10.1038/nmeth.3211. PMID:25506719<ref>PMID:25506719</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4wau" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Basilico, F]]
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[[Category: Homo sapiens]]
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[[Category: Cecatiello, V]]
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[[Category: Large Structures]]
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[[Category: Pasqualato, S]]
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[[Category: Basilico F]]
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[[Category: Wang, M]]
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[[Category: Cecatiello V]]
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[[Category: Weinert, T]]
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[[Category: Pasqualato S]]
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[[Category: Ccan]]
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[[Category: Wang M]]
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[[Category: Cell cycle]]
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[[Category: Weinert T]]
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[[Category: G-protein]]
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[[Category: Kinetochore]]
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[[Category: Mitosis]]
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[[Category: Native-sad]]
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[[Category: S-sad]]
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[[Category: Sulfur sad]]
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[[Category: Sulfur-sad]]
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Current revision

Crystal structure of CENP-M solved by native-SAD phasing

PDB ID 4wau

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