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5a3b

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==Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with ADP-ribose==
==Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with ADP-ribose==
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<StructureSection load='5a3b' size='340' side='right' caption='[[5a3b]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5a3b' size='340' side='right'caption='[[5a3b]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a3b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a3b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_str._Manfredo Streptococcus pyogenes str. Manfredo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A3B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a35|5a35]], [[5a3a|5a3a]], [[5a3c|5a3c]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3b OCA], [https://pdbe.org/5a3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a3b RCSB], [https://www.ebi.ac.uk/pdbsum/5a3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3b OCA], [http://pdbe.org/5a3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a3b RCSB], [http://www.ebi.ac.uk/pdbsum/5a3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3b ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q1JGN6_STRPD Q1JGN6_STRPD]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ahel, I]]
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[[Category: Large Structures]]
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[[Category: Ariza, A]]
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[[Category: Streptococcus pyogenes str. Manfredo]]
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[[Category: Barkauskaite, E]]
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[[Category: Ahel I]]
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[[Category: Cameron, D R]]
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[[Category: Ariza A]]
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[[Category: Kraehenbuehl, R]]
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[[Category: Barkauskaite E]]
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[[Category: Leidecker, O]]
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[[Category: Cameron DR]]
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[[Category: Leys, D]]
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[[Category: Kraehenbuehl R]]
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[[Category: Matic, I]]
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[[Category: Leidecker O]]
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[[Category: Morra, R]]
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[[Category: Leys D]]
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[[Category: Ortmayer, M]]
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[[Category: Matic I]]
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[[Category: Peleg, A Y]]
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[[Category: Morra R]]
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[[Category: Qu, Y]]
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[[Category: Ortmayer M]]
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[[Category: Rack, J G.M]]
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[[Category: Peleg AY]]
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[[Category: Traven, A]]
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[[Category: Qu Y]]
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[[Category: Adp-ribosyltransferase]]
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[[Category: Rack JGM]]
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[[Category: Lipoylation]]
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[[Category: Traven A]]
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[[Category: Metalloprotein]]
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[[Category: Nad-dependent]]
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[[Category: Regulatory enzyme]]
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[[Category: Ros defense]]
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[[Category: Rossmann fold]]
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[[Category: Transferase]]
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[[Category: Zinc binding]]
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Current revision

Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with ADP-ribose

PDB ID 5a3b

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