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5jho

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==Crystal structure of the regulatory domain of the sodium driven chloride bicarbonate exchanger.==
==Crystal structure of the regulatory domain of the sodium driven chloride bicarbonate exchanger.==
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<StructureSection load='5jho' size='340' side='right' caption='[[5jho]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='5jho' size='340' side='right'caption='[[5jho]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jho]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JHO FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jho OCA], [http://pdbe.org/5jho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jho RCSB], [http://www.ebi.ac.uk/pdbsum/5jho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jho ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jho OCA], [https://pdbe.org/5jho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jho RCSB], [https://www.ebi.ac.uk/pdbsum/5jho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jho ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/S4A8_HUMAN S4A8_HUMAN]] Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.<ref>PMID:10362779</ref> <ref>PMID:11133997</ref>
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[https://www.uniprot.org/uniprot/S4A8_HUMAN S4A8_HUMAN] Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.<ref>PMID:10362779</ref> <ref>PMID:11133997</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jho" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jho" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Anion exchange protein 3D structures|Anion exchange protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alvadia, C]]
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[[Category: Homo sapiens]]
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[[Category: Bjerregaard-Andersen, K]]
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[[Category: Large Structures]]
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[[Category: Morth, J P]]
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[[Category: Alvadia C]]
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[[Category: Sommer, T]]
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[[Category: Bjerregaard-Andersen K]]
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[[Category: Anion transport]]
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[[Category: Morth JP]]
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[[Category: Bicarbonate exchanger]]
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[[Category: Sommer T]]
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[[Category: Membrane protein]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the regulatory domain of the sodium driven chloride bicarbonate exchanger.

PDB ID 5jho

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