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5t8o

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<StructureSection load='5t8o' size='340' side='right'caption='[[5t8o]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='5t8o' size='340' side='right'caption='[[5t8o]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5t8o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T8O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5T8O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5t8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T8O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=76Z:10-(3-METHYL-3-OXIDANYL-BUT-1-YNYL)-5,6-DIHYDROIMIDAZO[1,2-D][1,4]BENZOXAZEPINE-2-CARBOXAMIDE'>76Z</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Map3k14, Nik ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=76Z:10-(3-METHYL-3-OXIDANYL-BUT-1-YNYL)-5,6-DIHYDROIMIDAZO[1,2-D][1,4]BENZOXAZEPINE-2-CARBOXAMIDE'>76Z</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t8o OCA], [https://pdbe.org/5t8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t8o RCSB], [https://www.ebi.ac.uk/pdbsum/5t8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t8o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5t8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t8o OCA], [http://pdbe.org/5t8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t8o RCSB], [http://www.ebi.ac.uk/pdbsum/5t8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t8o ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/M3K14_MOUSE M3K14_MOUSE]] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:11239468</ref>
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[https://www.uniprot.org/uniprot/M3K14_MOUSE M3K14_MOUSE] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:11239468</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Mitogen-activated protein kinase kinase kinase]]
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[[Category: Hymowitz SG]]
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[[Category: Hymowitz, S G]]
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[[Category: McEwan P]]
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[[Category: McEwan, P]]
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[[Category: Smith MA]]
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[[Category: Smith, M A]]
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[[Category: Map3k14]]
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[[Category: Nf-kappab]]
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[[Category: Protein serine/threonine kinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to Imidazobenzoxepin Compound 3

PDB ID 5t8o

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