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5t9j

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==Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface==
==Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface==
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<StructureSection load='5t9j' size='340' side='right' caption='[[5t9j]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='5t9j' size='340' side='right'caption='[[5t9j]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5t9j]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T9J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5t9j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T9J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0001273&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t9j OCA], [http://pdbe.org/5t9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t9j RCSB], [http://www.ebi.ac.uk/pdbsum/5t9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t9j ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t9j OCA], [https://pdbe.org/5t9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t9j RCSB], [https://www.ebi.ac.uk/pdbsum/5t9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t9j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GEN_HUMAN GEN_HUMAN]] Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.<ref>PMID:19020614</ref>
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[https://www.uniprot.org/uniprot/GEN_HUMAN GEN_HUMAN] Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.<ref>PMID:19020614</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Biertumpfel, C]]
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[[Category: Homo sapiens]]
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[[Category: Lee, S H]]
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[[Category: Large Structures]]
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[[Category: Dna four-way junction]]
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[[Category: Synthetic construct]]
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[[Category: Holliday junction resolvase]]
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[[Category: Biertumpfel C]]
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[[Category: Hydrolase]]
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[[Category: Lee S-H]]
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[[Category: Protein-dna complex]]
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[[Category: Structure-specific endonuclease]]
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Current revision

Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface

PDB ID 5t9j

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