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6f1e

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Crystal structure of olive flounder [Paralichthys olivaceus] interferon gamma at 2.3 Angstrom resolution

Structural highlights

6f1e is a 2 chain structure with sequence from Paralichthys olivaceus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.296Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IFNG_PAROL Cytokine which binds to interferon gamma receptor 1 (ifngr1) (PubMed:29742458). Also binds with lower affinity to interferon gamma receptor 1-like (ifngr1l) (PubMed:29742458). Has activating effects on macrophages and neutrophils (By similarity).[UniProtKB:B5B3U4]^[1]

Publication Abstract from PubMed

Interferon gamma (IFN-gamma) is one of the key players in the immune system of vertebrates. The evolution and properties of IFN-gamma and its receptors in fish species are of special interest as they point to the origin of innate immunity in vertebrates. We studied the phylogeny, biophysical and structural properties of IFN-gamma and its receptors. Our phylogeny analysis suggests the existence of two groups of IFN-gamma related proteins, one specific for Acanthomorpha, the other for Cypriniformes, Characiformes and Siluriformes. The analysis further shows an ancient duplication of the gene for IFN-gamma receptor 1 (IFN- gammaR1) and the parallel existence of the duplicated genes in all current teleost fish species. In contrast, only one gene can be found for receptor 2, IFN- gammaR2. The specificity of the interaction between IFN- gamma and both types of IFN- gammaR1 was determined by microscale thermophoresis measurements of the equilibrium dissociation constants for the proteins from three fish species. The measured preference of IFN- gamma for one of the two forms of receptor 1agrees with the bioinformatic analysis of the coevolution between IFN- gamma and receptor 1. To elucidate structural relationships between IFN-gamma of fish and other vertebrate species, we determined the crystal structure of IFN-gamma from olive flounder (Paralichthys olivaceus, PoliIFN-gamma) at crystallographic resolution of 2.3A and the low-resolution structures of Takifugu rubripes, Oreochromis niloticus, and Larimichthys crocea IFN-gamma by small angle X-ray diffraction. The overall PoliIFN-gamma fold is the same as the fold of the other known IFN- gamma structures but there are some significant structural differences, namely the additional C-terminal helix G and a different angle between helices C and D in PoliIFN-gamma.

Interferons type II and their receptors R1 and R2 in fish species: Evolution, structure, and function.,Zahradnik J, Kolarova L, Parizkova H, Kolenko P, Schneider B Fish Shellfish Immunol. 2018 May 6;79:140-152. doi: 10.1016/j.fsi.2018.05.008. PMID:29742458^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zahradnik J, Kolarova L, Parizkova H, Kolenko P, Schneider B. Interferons type II and their receptors R1 and R2 in fish species: Evolution, structure, and function. Fish Shellfish Immunol. 2018 May 6;79:140-152. doi: 10.1016/j.fsi.2018.05.008. PMID:29742458 doi:http://dx.doi.org/10.1016/j.fsi.2018.05.008
↑ Zahradnik J, Kolarova L, Parizkova H, Kolenko P, Schneider B. Interferons type II and their receptors R1 and R2 in fish species: Evolution, structure, and function. Fish Shellfish Immunol. 2018 May 6;79:140-152. doi: 10.1016/j.fsi.2018.05.008. PMID:29742458 doi:http://dx.doi.org/10.1016/j.fsi.2018.05.008

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6f1e"

@@ Line 1: / Line 1: @@
 ==Crystal structure of olive flounder [Paralichthys olivaceus] interferon gamma at 2.3 Angstrom resolution==
-<StructureSection load='6f1e' size='340' side='right' caption='[[6f1e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='6f1e' size='340' side='right'caption='[[6f1e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6f1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F1E FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6f1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paralichthys_olivaceus Paralichthys olivaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F1E FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f1e OCA], [http://pdbe.org/6f1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f1e RCSB], [http://www.ebi.ac.uk/pdbsum/6f1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f1e ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.296&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f1e OCA], [https://pdbe.org/6f1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f1e RCSB], [https://www.ebi.ac.uk/pdbsum/6f1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f1e ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/IFNG_PAROL IFNG_PAROL] Cytokine which binds to interferon gamma receptor 1 (ifngr1) (PubMed:29742458). Also binds with lower affinity to interferon gamma receptor 1-like (ifngr1l) (PubMed:29742458). Has activating effects on macrophages and neutrophils (By similarity).[UniProtKB:B5B3U4]<ref>PMID:29742458</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 20: @@
 ==See Also==
-*[[Interferon|Interferon]]
+*[[Interferon 3D structures|Interferon 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Kolarova, L]]
+[[Category: Large Structures]]
-[[Category: Kolenko, P]]
+[[Category: Paralichthys olivaceus]]
-[[Category: Schneider, B]]
+[[Category: Kolarova L]]
-[[Category: Zahradnik, J]]
+[[Category: Kolenko P]]
-[[Category: Antiviral defense]]
+[[Category: Schneider B]]
-[[Category: Four-helix bundle]]
+[[Category: Zahradnik J]]
-[[Category: Immune system]]
-[[Category: Interferon gamma]]

6f1e

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Current revision

Crystal structure of olive flounder [Paralichthys olivaceus] interferon gamma at 2.3 Angstrom resolution

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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