1u5l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:13, 9 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1u5l.png|left|200px]]
 
-
<!--
+
==Solution Structure of the turtle prion protein fragment (121-226)==
-
The line below this paragraph, containing "STRUCTURE_1u5l", creates the "Structure Box" on the page.
+
<StructureSection load='1u5l' size='340' side='right'caption='[[1u5l]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1u5l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trachemys_scripta Trachemys scripta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5L FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5l OCA], [https://pdbe.org/1u5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5l RCSB], [https://www.ebi.ac.uk/pdbsum/1u5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5l ProSAT]</span></td></tr>
-
{{STRUCTURE_1u5l| PDB=1u5l | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9I9C0_TRASC Q9I9C0_TRASC]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5l_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5l ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The NMR structures of the recombinant prion proteins from chicken (Gallus gallus; chPrP), the red-eared slider turtle (Trachemys scripta; tPrP), and the African clawed frog (Xenopus laevis; xlPrP) are presented. The amino acid sequences of these prion proteins show approximately 30% identity with mammalian prion proteins. All three species form the same molecular architecture as mammalian PrPC, with a long, flexibly disordered tail attached to the N-terminal end of a globular domain. The globular domain in chPrP and tPrP contains three alpha-helices, one short 3(10)-helix, and a short antiparallel beta-sheet. In xlPrP, the globular domain includes three alpha-helices and a somewhat longer beta-sheet than in the other species. The spatial arrangement of these regular secondary structures coincides closely with that of the globular domain in mammalian prion proteins. Based on the low sequence identity to mammalian PrPs, comparison of chPrP, tPrP, and xlPrP with mammalian PrPC structures is used to identify a set of essential amino acid positions for the preservation of the same PrPC fold in birds, reptiles, amphibians, and mammals. There are additional conserved residues without apparent structural roles, which are of interest for the ongoing search for physiological functions of PrPC in healthy organisms.
-
===Solution Structure of the turtle prion protein fragment (121-226)===
+
Prion protein NMR structures of chickens, turtles, and frogs.,Calzolai L, Lysek DA, Perez DR, Guntert P, Wuthrich K Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):651-5. Epub 2005 Jan 12. PMID:15647366<ref>PMID:15647366</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1u5l" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_15647366}}, adds the Publication Abstract to the page
+
*[[Prion 3D structures|Prion 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 15647366 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_15647366}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1U5L is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Trachemys_scripta Trachemys scripta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5L OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:15647366</ref><references group="xtra"/>
+
[[Category: Trachemys scripta]]
[[Category: Trachemys scripta]]
-
[[Category: Calzolai, L.]]
+
[[Category: Calzolai L]]
-
[[Category: Guntert, P.]]
+
[[Category: Guntert P]]
-
[[Category: Lysek, D A.]]
+
[[Category: Lysek DA]]
-
[[Category: Wuthrich, K.]]
+
[[Category: Wuthrich K]]
-
[[Category: Prion]]
+
-
[[Category: Prnp]]
+
-
[[Category: Prp]]
+
-
[[Category: Tse]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:40:48 2009''
+

Current revision

Solution Structure of the turtle prion protein fragment (121-226)

PDB ID 1u5l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u5l"
Personal tools