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1uuh

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<StructureSection load='1uuh' size='340' side='right'caption='[[1uuh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1uuh' size='340' side='right'caption='[[1uuh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1uuh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UUH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1uuh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UUH FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uuh OCA], [http://pdbe.org/1uuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uuh RCSB], [http://www.ebi.ac.uk/pdbsum/1uuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uuh ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uuh OCA], [https://pdbe.org/1uuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uuh RCSB], [https://www.ebi.ac.uk/pdbsum/1uuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uuh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN]] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
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[https://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Banerji, S]]
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[[Category: Banerji S]]
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[[Category: Blundell, C]]
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[[Category: Blundell C]]
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[[Category: Campbell, I]]
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[[Category: Campbell I]]
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[[Category: Day, A]]
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[[Category: Day A]]
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[[Category: Jackson, D]]
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[[Category: Jackson D]]
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[[Category: Kahmann, J]]
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[[Category: Kahmann J]]
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[[Category: Lowe, E]]
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[[Category: Lowe E]]
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[[Category: Mahoney, D]]
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[[Category: Mahoney D]]
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[[Category: Noble, M]]
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[[Category: Noble M]]
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[[Category: Pickford, A]]
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[[Category: Pickford A]]
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[[Category: Tammi, M]]
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[[Category: Tammi M]]
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[[Category: Teriete, P]]
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[[Category: Teriete P]]
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[[Category: Wright, A]]
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[[Category: Wright A]]
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[[Category: C- type lectin]]
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[[Category: Extracellular matrix]]
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[[Category: Hyaluronan]]
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[[Category: Lectin]]
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[[Category: Link-domain]]
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[[Category: Receptor]]
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[[Category: Sugar-binding]]
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Current revision

Hyaluronan binding domain of human CD44

PDB ID 1uuh

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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