1uzc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1uzc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzc" /> '''THE STRUCTURE OF AN FF DOMAIN FROM HUMAN HYP...)
Current revision (13:23, 9 May 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1uzc.gif|left|200px]]<br /><applet load="1uzc" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1uzc" />
 
-
'''THE STRUCTURE OF AN FF DOMAIN FROM HUMAN HYPA/FBP11'''<br />
 
-
==Overview==
+
==THE STRUCTURE OF AN FF DOMAIN FROM HUMAN HYPA/FBP11==
-
The FF domain is a 60 amino acid residue phosphopeptide-binding module, found in a variety of eukaryotic proteins including the transcription, elongation factor CA150, the splicing factor Prp40 and p190RHOGAP. We have, determined the structure of an FF domain from HYPA/FBP11. The domain is, composed of three alpha helices arranged in an orthogonal bundle with a, 3(10) helix in the loop between the second and third alpha helices. The, structure differs from those of other phosphopeptide-binding domains and, represents a novel phosphopeptide-binding fold.
+
<StructureSection load='1uzc' size='340' side='right'caption='[[1uzc]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1uzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1h40 1h40]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UZC FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uzc OCA], [https://pdbe.org/1uzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uzc RCSB], [https://www.ebi.ac.uk/pdbsum/1uzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uzc ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PR40A_HUMAN PR40A_HUMAN] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.<ref>PMID:21834987</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/1uzc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uzc ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The FF domain is a 60 amino acid residue phosphopeptide-binding module found in a variety of eukaryotic proteins including the transcription elongation factor CA150, the splicing factor Prp40 and p190RHOGAP. We have determined the structure of an FF domain from HYPA/FBP11. The domain is composed of three alpha helices arranged in an orthogonal bundle with a 3(10) helix in the loop between the second and third alpha helices. The structure differs from those of other phosphopeptide-binding domains and represents a novel phosphopeptide-binding fold.
-
==About this Structure==
+
The structure of an FF domain from human HYPA/FBP11.,Allen M, Friedler A, Schon O, Bycroft M J Mol Biol. 2002 Oct 25;323(3):411-6. PMID:12381297<ref>PMID:12381297</ref>
-
1UZC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure superseeds the now removed PDB entry 1H40. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZC OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
The structure of an FF domain from human HYPA/FBP11., Allen M, Friedler A, Schon O, Bycroft M, J Mol Biol. 2002 Oct 25;323(3):411-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12381297 12381297]
+
</div>
 +
<div class="pdbe-citations 1uzc" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Allen, M.D.]]
+
[[Category: Allen MD]]
-
[[Category: Bycroft, M.]]
+
[[Category: Bycroft M]]
-
[[Category: Friedler, A.]]
+
[[Category: Friedler A]]
-
[[Category: Jemth, P.]]
+
[[Category: Jemth P]]
-
[[Category: Schon, O.]]
+
[[Category: Schon O]]
-
[[Category: nmr structure]]
+
-
[[Category: nuclear protein]]
+
-
[[Category: phosphopeptide recognition]]
+
-
[[Category: rna polymerase ii carboxyl-terminal domain]]
+
-
[[Category: transcription]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:22:01 2007''
+

Current revision

THE STRUCTURE OF AN FF DOMAIN FROM HUMAN HYPA/FBP11

PDB ID 1uzc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uzc"
Personal tools