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1vlk

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[[Image:1vlk.gif|left|200px]]
 
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==STRUCTURE OF VIRAL INTERLEUKIN-10==
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The line below this paragraph, containing "STRUCTURE_1vlk", creates the "Structure Box" on the page.
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<StructureSection load='1vlk' size='340' side='right'caption='[[1vlk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vlk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VLK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vlk OCA], [https://pdbe.org/1vlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vlk RCSB], [https://www.ebi.ac.uk/pdbsum/1vlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vlk ProSAT]</span></td></tr>
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{{STRUCTURE_1vlk| PDB=1vlk | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL10H_EBVB9 IL10H_EBVB9] Plays a role in masking infected cells for immune recognition by cytotoxic T-lymphocytes. Down-regulates the expression of the host TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Inhibits IFN-gamma synthesis.<ref>PMID:2161559</ref> <ref>PMID:9310490</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/1vlk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vlk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of Epstein-Barr virus protein BCRF1, an analog of cellular interleukin-10 (IL-10), has been determined at the resolution of 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is similar to that of human IL-10 (hIL-10), forming an intercalated dimer of two 17 kDa polypeptides related by a crystallographic 2-fold symmetry axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the loop between helices A and B compared to hIL-10. These regions are likely to be involved in binding of one or more components of the IL-10 receptor system, and thus the structural differences may account for the lower binding affinity and limited spectrum of biological activities of viral IL-10, compared to hIL-10.
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'''STRUCTURE OF VIRAL INTERLEUKIN-10'''
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Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10.,Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A J Mol Biol. 1997 May 2;268(2):460-7. PMID:9159483<ref>PMID:9159483</ref>
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==Overview==
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The crystal structure of Epstein-Barr virus protein BCRF1, an analog of cellular interleukin-10 (IL-10), has been determined at the resolution of 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is similar to that of human IL-10 (hIL-10), forming an intercalated dimer of two 17 kDa polypeptides related by a crystallographic 2-fold symmetry axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the loop between helices A and B compared to hIL-10. These regions are likely to be involved in binding of one or more components of the IL-10 receptor system, and thus the structural differences may account for the lower binding affinity and limited spectrum of biological activities of viral IL-10, compared to hIL-10.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1VLK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VLK OCA].
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</div>
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<div class="pdbe-citations 1vlk" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10., Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A, J Mol Biol. 1997 May 2;268(2):460-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9159483 9159483]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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[[Category: Human herpesvirus 4]]
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== References ==
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[[Category: Single protein]]
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<references/>
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[[Category: Schalk-Hihi, C.]]
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__TOC__
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[[Category: Wlodawer, A.]]
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</StructureSection>
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[[Category: Zdanov, A.]]
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[[Category: Human gammaherpesvirus 4]]
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[[Category: Cytokine]]
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[[Category: Large Structures]]
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[[Category: Glycoprotein]]
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[[Category: Schalk-Hihi C]]
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[[Category: Signal]]
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[[Category: Wlodawer A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:41:06 2008''
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[[Category: Zdanov A]]

Current revision

STRUCTURE OF VIRAL INTERLEUKIN-10

PDB ID 1vlk

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