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1wcx

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[[Image:1wcx.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of Mutant Uroporphyrinogen III Synthase from an Extremely Thermophilic Bacterium Thermus thermophilus HB8 (L75M/I193M/L248M, SeMet derivative, Form-1 crystal)==
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|PDB= 1wcx |SIZE=350|CAPTION= <scene name='initialview01'>1wcx</scene>, resolution 2.00&Aring;
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<StructureSection load='1wcx' size='340' side='right'caption='[[1wcx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1wcx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCX FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Uroporphyrinogen-III_synthase Uroporphyrinogen-III synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.75 4.2.1.75]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wcx OCA], [https://pdbe.org/1wcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wcx RCSB], [https://www.ebi.ac.uk/pdbsum/1wcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wcx ProSAT], [https://www.topsan.org/Proteins/RSGI/1wcx TOPSAN]</span></td></tr>
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</table>
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'''Crystal Structure of Mutant Uroporphyrinogen III Synthase from an Extremely Thermophilic Bacterium Thermus thermophilus HB8 (L75M/I193M/L248M, SeMet derivative, Form-1 crystal)'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q5SKH2_THET8 Q5SKH2_THET8]
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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1WCX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCX OCA].
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Check<jmol>
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[[Category: Single protein]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wcx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wcx ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Uroporphyrinogen-III synthase]]
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[[Category: Kuramitsu S]]
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[[Category: Kuramitsu, S.]]
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[[Category: Matsuura T]]
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[[Category: Matsuura, T.]]
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[[Category: Mizohata E]]
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[[Category: Mizohata, E.]]
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[[Category: Murayama K]]
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[[Category: Murayama, K.]]
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[[Category: Sakai H]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Sakai, H.]]
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[[Category: Terada T]]
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[[Category: Shirouzu, M.]]
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[[Category: Yokoyama S]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: GOL]]
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[[Category: congenital erythropoietic porphyria]]
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[[Category: porphyrin]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: uroporphyrinogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:55:22 2008''
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Current revision

Crystal Structure of Mutant Uroporphyrinogen III Synthase from an Extremely Thermophilic Bacterium Thermus thermophilus HB8 (L75M/I193M/L248M, SeMet derivative, Form-1 crystal)

PDB ID 1wcx

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