1weu

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[[Image:1weu.jpg|left|200px]]
 
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{{Structure
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==Solution structure of PHD domain in ING1-like protein BAC25009==
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|PDB= 1weu |SIZE=350|CAPTION= <scene name='initialview01'>1weu</scene>
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<StructureSection load='1weu' size='340' side='right'caption='[[1weu]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1weu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WEU FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= RIKEN cDNA 0610039A16 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1weu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1weu OCA], [https://pdbe.org/1weu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1weu RCSB], [https://www.ebi.ac.uk/pdbsum/1weu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1weu ProSAT], [https://www.topsan.org/Proteins/RSGI/1weu TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1weu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1weu OCA], [http://www.ebi.ac.uk/pdbsum/1weu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1weu RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/ING4_MOUSE ING4_MOUSE] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity).
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== Evolutionary Conservation ==
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'''Solution structure of PHD domain in ING1-like protein BAC25009'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/1weu_consurf.spt"</scriptWhenChecked>
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1WEU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WEU OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1weu ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: He F]]
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[[Category: He, F.]]
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[[Category: Inoue M]]
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[[Category: Inoue, M.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Muto Y]]
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[[Category: Muto, Y.]]
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[[Category: Shirouzu M]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Terada T]]
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[[Category: Shirouzu, M.]]
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[[Category: Yokoyama S]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: dna binding protein]]
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[[Category: ing1-like protein]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nmr]]
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[[Category: nppsfa]]
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[[Category: phd domain]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:35:18 2008''
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Current revision

Solution structure of PHD domain in ING1-like protein BAC25009

PDB ID 1weu

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OCA

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