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1wfl

From Proteopedia

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{{Seed}}
 
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[[Image:1wfl.png|left|200px]]
 
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==Solution structure of the zf-AN1 domain from mouse zinc finger protein 216==
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The line below this paragraph, containing "STRUCTURE_1wfl", creates the "Structure Box" on the page.
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<StructureSection load='1wfl' size='340' side='right'caption='[[1wfl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wfl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WFL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1wfl| PDB=1wfl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfl OCA], [https://pdbe.org/1wfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfl RCSB], [https://www.ebi.ac.uk/pdbsum/1wfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfl ProSAT], [https://www.topsan.org/Proteins/RSGI/1wfl TOPSAN]</span></td></tr>
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</table>
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===Solution structure of the zf-AN1 domain from mouse zinc finger protein 216===
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== Function ==
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[https://www.uniprot.org/uniprot/ZFAN5_MOUSE ZFAN5_MOUSE] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.<ref>PMID:16194934</ref> <ref>PMID:16424905</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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1WFL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFL OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/1wfl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wfl ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Inoue M]]
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[[Category: Inoue, M.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S.]]
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[[Category: Tomizawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Tomizawa, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Zf-an1 domain]]
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[[Category: Zinc binding]]
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[[Category: Zinc finger protein 216]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 15:14:20 2008''
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Current revision

Solution structure of the zf-AN1 domain from mouse zinc finger protein 216

PDB ID 1wfl

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