This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1wge
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of the mouse DESR1== | ==Solution structure of the mouse DESR1== | ||
| - | <StructureSection load='1wge' size='340' side='right'caption='[[1wge | + | <StructureSection load='1wge' size='340' side='right'caption='[[1wge]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wge]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1wge]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WGE FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wge OCA], [https://pdbe.org/1wge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wge RCSB], [https://www.ebi.ac.uk/pdbsum/1wge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wge ProSAT], [https://www.topsan.org/Proteins/RSGI/1wge TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wge OCA], [https://pdbe.org/1wge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wge RCSB], [https://www.ebi.ac.uk/pdbsum/1wge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wge ProSAT], [https://www.topsan.org/Proteins/RSGI/1wge TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DPH3_MOUSE DPH3_MOUSE] Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2. Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5 (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 23: | Line 23: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Nakanishi | + | [[Category: Nakanishi T]] |
| - | + | [[Category: Tochio N]] | |
| - | [[Category: Tochio | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure of the mouse DESR1
| |||||||||||
Categories: Large Structures | Mus musculus | Inoue M | Kigawa T | Koshiba S | Nakanishi T | Tochio N | Yokoyama S
