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1wji

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==Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3==
==Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3==
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<StructureSection load='1wji' size='340' side='right' caption='[[1wji]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1wji' size='340' side='right'caption='[[1wji]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wji]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WJI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJI FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMS cDNA CAE03871 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wji OCA], [http://pdbe.org/1wji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wji RCSB], [http://www.ebi.ac.uk/pdbsum/1wji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wji ProSAT], [http://www.topsan.org/Proteins/RSGI/1wji TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wji OCA], [https://pdbe.org/1wji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wji RCSB], [https://www.ebi.ac.uk/pdbsum/1wji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wji ProSAT], [https://www.topsan.org/Proteins/RSGI/1wji TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TDRD3_HUMAN TDRD3_HUMAN]] Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.<ref>PMID:18632687</ref> <ref>PMID:15955813</ref> <ref>PMID:21172665</ref>
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[https://www.uniprot.org/uniprot/TDRD3_HUMAN TDRD3_HUMAN] Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.<ref>PMID:18632687</ref> <ref>PMID:15955813</ref> <ref>PMID:21172665</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Inoue, M]]
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[[Category: Large Structures]]
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[[Category: Kamatari, Y O]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kamatari YO]]
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[[Category: Kobayashi, N]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Kobayashi N]]
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[[Category: Li, H]]
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[[Category: Koshiba S]]
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[[Category: Miyamoto, K]]
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[[Category: Li H]]
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[[Category: Nakanishi, T]]
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[[Category: Miyamoto K]]
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[[Category: Structural genomic]]
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[[Category: Nakanishi T]]
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[[Category: Tochio, N]]
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[[Category: Tochio N]]
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[[Category: Tomizawa, T]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Rsgi]]
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[[Category: Tudor domain containing 3]]
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[[Category: Uba domain]]
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[[Category: Unknown function]]
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Current revision

Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3

PDB ID 1wji

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