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1wji

From Proteopedia

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{{Seed}}
 
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[[Image:1wji.png|left|200px]]
 
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==Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3==
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The line below this paragraph, containing "STRUCTURE_1wji", creates the "Structure Box" on the page.
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<StructureSection load='1wji' size='340' side='right'caption='[[1wji]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wji OCA], [https://pdbe.org/1wji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wji RCSB], [https://www.ebi.ac.uk/pdbsum/1wji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wji ProSAT], [https://www.topsan.org/Proteins/RSGI/1wji TOPSAN]</span></td></tr>
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{{STRUCTURE_1wji| PDB=1wji | SCENE= }}
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</table>
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== Function ==
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===Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3===
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[https://www.uniprot.org/uniprot/TDRD3_HUMAN TDRD3_HUMAN] Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.<ref>PMID:18632687</ref> <ref>PMID:15955813</ref> <ref>PMID:21172665</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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1WJI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJI OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/1wji_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wji ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kamatari, Y O.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kamatari YO]]
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[[Category: Kobayashi, N.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Kobayashi N]]
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[[Category: Li, H.]]
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[[Category: Koshiba S]]
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[[Category: Miyamoto, K.]]
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[[Category: Li H]]
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[[Category: Nakanishi, T.]]
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[[Category: Miyamoto K]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nakanishi T]]
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[[Category: Tochio, N.]]
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[[Category: Tochio N]]
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[[Category: Tomizawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tudor domain containing 3]]
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[[Category: Uba domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 15:01:02 2008''
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Current revision

Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3

PDB ID 1wji

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