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1wlx

From Proteopedia

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[[Image:1wlx.png|left|200px]]
 
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==Solution structure of the third spectrin repeat of alpha-actinin-4==
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The line below this paragraph, containing "STRUCTURE_1wlx", creates the "Structure Box" on the page.
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<StructureSection load='1wlx' size='340' side='right'caption='[[1wlx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wlx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WLX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wlx OCA], [https://pdbe.org/1wlx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wlx RCSB], [https://www.ebi.ac.uk/pdbsum/1wlx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wlx ProSAT]</span></td></tr>
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{{STRUCTURE_1wlx| PDB=1wlx | SCENE= }}
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</table>
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== Disease ==
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===Solution structure of the third spectrin repeat of alpha-actinin-4===
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[https://www.uniprot.org/uniprot/ACTN4_HUMAN ACTN4_HUMAN] Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1) [MIM:[https://omim.org/entry/603278 603278]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:10700177</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTN4_HUMAN ACTN4_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
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==About this Structure==
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== Evolutionary Conservation ==
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[[1wlx]] is a 1 chain structure of [[Actinin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLX OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/1wlx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wlx ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Actinin]]
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*[[Actinin 3D structures|Actinin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Booker, G W.]]
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[[Category: Large Structures]]
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[[Category: Kowalski, K.]]
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[[Category: Booker GW]]
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[[Category: Merkel, A L.]]
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[[Category: Kowalski K]]
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[[Category: Protein binding]]
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[[Category: Merkel AL]]
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[[Category: Three-helix bundle]]
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Current revision

Solution structure of the third spectrin repeat of alpha-actinin-4

PDB ID 1wlx

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OCA

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