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1wq9

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[[Image:1wq9.png|left|200px]]
 
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==Crystal structure of VR-1, a VEGF-F from a snake venom==
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The line below this paragraph, containing "STRUCTURE_1wq9", creates the "Structure Box" on the page.
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<StructureSection load='1wq9' size='340' side='right'caption='[[1wq9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wq9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_russelii Daboia russelii russelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WQ9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_1wq9| PDB=1wq9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wq9 OCA], [https://pdbe.org/1wq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wq9 RCSB], [https://www.ebi.ac.uk/pdbsum/1wq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wq9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TXVE_DABRR TXVE_DABRR] Induces angiogenesis probably through VEGF receptor (VEGFR) signaling, as well as drastic hypotension. The hypotension is mediated by nitric oxide, which is produced by VEGF-activated endothelium NO synthase. May also induce capillary permeability.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/1wq9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wq9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vascular endothelial growth factor-A (VEGF-A(165)) exerts multiple effects upon binding to the fms-like tyrosine kinase-1 (Flt-1) and the kinase insert domain-containing receptor (KDR). We recently identified two novel snake venom VEGFs (vammin and VR-1) having unique properties. These VEGFs, designated VEGF-Fs, are highly specific ligands for the kinase insert domain-containing receptor and exhibit potent biological activity both in vitro and in vivo when compared with VEGF-A(165). Here, we solved the crystal structures of vammin and VR-1 at 1.9 and 2.0 A resolutions, respectively. Both structures are very similar to each other, and these structures exhibit similar but significantly different features from the known structures of other VEGFs. These differences include a conformational difference in receptor-binding loop 3 caused by an amino acid residue insertion and a difference in surface potential on the possible binding surface for domain 3 of the receptor. These structural differences may be related to the highly selective ligand properties of VEGF-F.
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===Crystal structure of VR-1, a VEGF-F from a snake venom===
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Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.,Suto K, Yamazaki Y, Morita T, Mizuno H J Biol Chem. 2005 Jan 21;280(3):2126-31. Epub 2004 Nov 12. PMID:15542594<ref>PMID:15542594</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15542594}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1wq9" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15542594 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15542594}}
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==About this Structure==
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[[1wq9]] is a 2 chain structure of [[Vascular Endothelial Growth Factor]] with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_russellii Daboia russellii russellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ9 OCA].
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==See Also==
==See Also==
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*[[Vascular Endothelial Growth Factor|Vascular Endothelial Growth Factor]]
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*[[VEGF 3D Structures|VEGF 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015542594</ref><ref group="xtra">PMID:014600159</ref><references group="xtra"/>
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__TOC__
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[[Category: Daboia russellii russellii]]
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</StructureSection>
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[[Category: Mizuno, H.]]
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[[Category: Daboia russelii russelii]]
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[[Category: Morita, T.]]
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[[Category: Large Structures]]
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[[Category: Suto, K.]]
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[[Category: Mizuno H]]
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[[Category: Yamazaki, Y.]]
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[[Category: Morita T]]
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[[Category: Snake venom]]
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[[Category: Suto K]]
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[[Category: Toxin]]
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[[Category: Yamazaki Y]]
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[[Category: Vascular endothelial growth factor]]
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[[Category: Vegf]]
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[[Category: Vegf-f]]
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Current revision

Crystal structure of VR-1, a VEGF-F from a snake venom

PDB ID 1wq9

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