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1wt9

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(New page: 200px<br /><applet load="1wt9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wt9, resolution 2.01&Aring;" /> '''crystal structure of...)
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[[Image:1wt9.gif|left|200px]]<br /><applet load="1wt9" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1wt9, resolution 2.01&Aring;" />
 
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'''crystal structure of Aa-X-bp-I, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus'''<br />
 
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==About this Structure==
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==crystal structure of Aa-X-bp-I, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus==
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1WT9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WT9 OCA].
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<StructureSection load='1wt9' size='340' side='right'caption='[[1wt9]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wt9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WT9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wt9 OCA], [https://pdbe.org/1wt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wt9 RCSB], [https://www.ebi.ac.uk/pdbsum/1wt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wt9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SLUA_DEIAC SLUA_DEIAC] Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX (F9) and factor X (F10) in the presence of calcium with a 1 to 1 stoichiometry. Also inhibits platelet aggregation by binding to platelet glycoprotein Ibalpha (GP1BA) and functioning as a blocker of von Willebrand factor (VWF). Is devoid of hemorrhagic and lethal activities. Possesses antithrombotic and thrombolytic activities. Also hydrolyzes the Aalpha-chain of fibrinogen (FGA). Does not affect the Bbeta-chain (FGB) and the gamma chain (FGG).<ref>PMID:10558903</ref> <ref>PMID:12058182</ref> <ref>PMID:15925567</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/1wt9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wt9 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Deinagkistrodon acutus]]
[[Category: Deinagkistrodon acutus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Liang, Z.]]
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[[Category: Liang Z]]
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[[Category: Liu, S.]]
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[[Category: Liu S]]
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[[Category: Mo, X.]]
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[[Category: Mo X]]
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[[Category: Niu, L.]]
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[[Category: Niu L]]
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[[Category: Teng, M.]]
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[[Category: Teng M]]
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[[Category: Yu, X.]]
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[[Category: Yu X]]
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[[Category: Zang, J.]]
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[[Category: Zang J]]
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[[Category: Zhao, W.]]
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[[Category: Zhao W]]
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[[Category: Zhu, Z.]]
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[[Category: Zhu Z]]
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[[Category: CA]]
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[[Category: aa-x-bp-i]]
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[[Category: agksitrodon acutus]]
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[[Category: c-type lectin-like proteins]]
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[[Category: snake venom]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:39:54 2007''
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Current revision

crystal structure of Aa-X-bp-I, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus

PDB ID 1wt9

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