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1wta

From Proteopedia

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(New page: 200px<br /><applet load="1wta" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wta, resolution 1.78&Aring;" /> '''Crystal Structure of...)
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[[Image:1wta.gif|left|200px]]<br /><applet load="1wta" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1wta, resolution 1.78&Aring;" />
 
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'''Crystal Structure of 5'-Deoxy-5'-methylthioadenosine from Aeropyrum pernix (R32 form)'''<br />
 
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==About this Structure==
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==Crystal Structure of 5'-Deoxy-5'-methylthioadenosine from Aeropyrum pernix (R32 form)==
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1WTA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aeropyrum_pernix_k1 Aeropyrum pernix k1] with PO4 and ADE as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/S-methyl-5-thioadenosine_phosphorylase S-methyl-5-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WTA OCA].
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<StructureSection load='1wta' size='340' side='right'caption='[[1wta]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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[[Category: Aeropyrum pernix k1]]
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== Structural highlights ==
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[[Category: S-methyl-5-thioadenosine phosphorylase]]
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<table><tr><td colspan='2'>[[1wta]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix_K1 Aeropyrum pernix K1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WTA FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
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[[Category: Murakami, Y.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Nakamura, K.T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wta OCA], [https://pdbe.org/1wta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wta RCSB], [https://www.ebi.ac.uk/pdbsum/1wta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wta ProSAT]</span></td></tr>
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[[Category: Tsunoda, M.]]
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</table>
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[[Category: ADE]]
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== Function ==
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[[Category: PO4]]
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[https://www.uniprot.org/uniprot/MTAP_AERPE MTAP_AERPE] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.[HAMAP-Rule:MF_01963]
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[[Category: a/b structure]]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/1wta_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wta ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:40:12 2007''
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==See Also==
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*[[5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures|5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Aeropyrum pernix K1]]
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[[Category: Large Structures]]
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[[Category: Murakami Y]]
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[[Category: Nakamura KT]]
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[[Category: Tsunoda M]]

Current revision

Crystal Structure of 5'-Deoxy-5'-methylthioadenosine from Aeropyrum pernix (R32 form)

PDB ID 1wta

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