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1wxm

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Current revision (13:53, 9 May 2024) (edit) (undo)
 
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==Solution Structure of the N-terminal Ras-binding Domain (RBD) in Human a-Raf Kinase==
==Solution Structure of the N-terminal Ras-binding Domain (RBD) in Human a-Raf Kinase==
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<StructureSection load='1wxm' size='340' side='right'caption='[[1wxm]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1wxm' size='340' side='right'caption='[[1wxm]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXM FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARAF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transferase Transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxm OCA], [https://pdbe.org/1wxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxm RCSB], [https://www.ebi.ac.uk/pdbsum/1wxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxm ProSAT], [https://www.topsan.org/Proteins/RSGI/1wxm TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxm OCA], [https://pdbe.org/1wxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxm RCSB], [https://www.ebi.ac.uk/pdbsum/1wxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxm ProSAT], [https://www.topsan.org/Proteins/RSGI/1wxm TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ARAF_HUMAN ARAF_HUMAN]] Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.<ref>PMID:17535970</ref> Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.<ref>PMID:17535970</ref>
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[https://www.uniprot.org/uniprot/ARAF_HUMAN ARAF_HUMAN] Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.<ref>PMID:17535970</ref> Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.<ref>PMID:17535970</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Inoue M]]
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[[Category: Inoue, M]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S]]
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[[Category: Tochio N]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Tochio, N]]
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[[Category: Zhao C]]
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[[Category: Yokoyama, S]]
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[[Category: Zhao, C]]
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[[Category: A-raf kinase]]
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[[Category: Rsgi]]
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[[Category: Ubiquitin-like fold]]
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Current revision

Solution Structure of the N-terminal Ras-binding Domain (RBD) in Human a-Raf Kinase

PDB ID 1wxm

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