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1wz0

From Proteopedia

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[[Image:1wz0.gif|left|200px]]<br /><applet load="1wz0" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1wz0" />
 
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'''Solution Structure of Human SUMO-2 (SMT3B), a Ubiquitin-like Protein'''<br />
 
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==About this Structure==
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==Solution Structure of Human SUMO-2 (SMT3B), a Ubiquitin-like Protein==
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1WZ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ0 OCA].
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<StructureSection load='1wz0' size='340' side='right'caption='[[1wz0]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1wz0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WZ0 FirstGlance]. <br>
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[[Category: Inoue, M.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Kigawa, T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wz0 OCA], [https://pdbe.org/1wz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wz0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wz0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wz0 TOPSAN]</span></td></tr>
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[[Category: Koshiba, S.]]
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</table>
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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== Function ==
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[[Category: Saito, K.]]
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[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
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[[Category: Yokoyama, S.]]
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== Evolutionary Conservation ==
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[[Category: Zhao, C.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: nppfsa]]
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Check<jmol>
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[[Category: riken structural genomics/proteomics initiative]]
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<jmolCheckbox>
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[[Category: rsgi]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/1wz0_consurf.spt"</scriptWhenChecked>
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[[Category: sentrin2]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: structural genomics]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: sumo-2]]
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</jmolCheckbox>
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[[Category: ubiquitin-like molecule]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wz0 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:49:30 2008''
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==See Also==
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*[[SUMO 3D Structures|SUMO 3D Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Saito K]]
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[[Category: Yokoyama S]]
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[[Category: Zhao C]]

Current revision

Solution Structure of Human SUMO-2 (SMT3B), a Ubiquitin-like Protein

PDB ID 1wz0

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