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1x0n

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Current revision (13:55, 9 May 2024) (edit) (undo)
 
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==NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor==
==NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor==
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<StructureSection load='1x0n' size='340' side='right'caption='[[1x0n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1x0n' size='340' side='right'caption='[[1x0n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X0N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X0N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTF:4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC+ACID'>DTF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTF:4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC+ACID'>DTF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x0n OCA], [https://pdbe.org/1x0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x0n RCSB], [https://www.ebi.ac.uk/pdbsum/1x0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x0n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x0n OCA], [https://pdbe.org/1x0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x0n RCSB], [https://www.ebi.ac.uk/pdbsum/1x0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x0n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
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[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Burke, T R]]
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[[Category: Burke TR]]
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[[Category: Inagaki, F]]
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[[Category: Inagaki F]]
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[[Category: Ogura, K]]
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[[Category: Ogura K]]
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[[Category: Shiga, T]]
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[[Category: Shiga T]]
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[[Category: Yokochi, M]]
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[[Category: Yokochi M]]
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[[Category: Yuzawa, S]]
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[[Category: Yuzawa S]]
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[[Category: Peptide binding protein]]
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Current revision

NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor

PDB ID 1x0n

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