This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1x44

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1x44" [edit=sysop:move=sysop])
Current revision (13:57, 9 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1x44.png|left|200px]]
 
-
{{STRUCTURE_1x44| PDB=1x44 | SCENE= }}
+
==Solution structure of the third ig-like domain of Myosin-dinding protein C, slow-type==
-
 
+
<StructureSection load='1x44' size='340' side='right'caption='[[1x44]]' scene=''>
-
===Solution structure of the third ig-like domain of Myosin-dinding protein C, slow-type===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1x44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X44 FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x44 OCA], [https://pdbe.org/1x44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x44 RCSB], [https://www.ebi.ac.uk/pdbsum/1x44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x44 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x44 TOPSAN]</span></td></tr>
-
[[1x44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X44 OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[https://omim.org/entry/614335 614335]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN] Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x44_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x44 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Hayashi, F.]]
+
[[Category: Large Structures]]
-
[[Category: Kurosaki, C.]]
+
[[Category: Hayashi F]]
-
[[Category: Qin, X R.]]
+
[[Category: Kurosaki C]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Qin X-R]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yoshida, M.]]
+
[[Category: Yoshida M]]
-
[[Category: Contractile protein]]
+
-
[[Category: Ig-like domain]]
+
-
[[Category: Myosin-binding protein c]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Slow-type/skeletal muscle slow-isoform]]
+
-
[[Category: Structural genomic]]
+

Current revision

Solution structure of the third ig-like domain of Myosin-dinding protein C, slow-type

PDB ID 1x44

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x44"
Personal tools