1x4k
From Proteopedia
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| - | {{STRUCTURE_1x4k| PDB=1x4k | SCENE= }} | ||
| - | ===Solution structure of LIM domain in LIM-protein 3=== | ||
| - | == | + | ==Solution structure of LIM domain in LIM-protein 3== |
| - | [[1x4k]] is a 1 chain structure with sequence from [ | + | <StructureSection load='1x4k' size='340' side='right'caption='[[1x4k]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1x4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X4K FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4k OCA], [https://pdbe.org/1x4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x4k RCSB], [https://www.ebi.ac.uk/pdbsum/1x4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4k ProSAT], [https://www.topsan.org/Proteins/RSGI/1x4k TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FHL2_HUMAN FHL2_HUMAN] May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.<ref>PMID:15692560</ref> <ref>PMID:16652157</ref> <ref>PMID:18853468</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4k_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x4k ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Muscle LIM protein|Muscle LIM protein]] | *[[Muscle LIM protein|Muscle LIM protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: He | + | [[Category: Large Structures]] |
| - | [[Category: Inoue | + | [[Category: He F]] |
| - | [[Category: Kigawa | + | [[Category: Inoue M]] |
| - | [[Category: Muto | + | [[Category: Kigawa T]] |
| - | + | [[Category: Muto Y]] | |
| - | [[Category: Shirouzu | + | [[Category: Shirouzu M]] |
| - | [[Category: Terada | + | [[Category: Terada T]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution structure of LIM domain in LIM-protein 3
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Categories: Homo sapiens | Large Structures | He F | Inoue M | Kigawa T | Muto Y | Shirouzu M | Terada T | Yokoyama S
