1x4q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:58, 9 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1x4q.png|left|200px]]
 
-
{{STRUCTURE_1x4q| PDB=1x4q | SCENE= }}
+
==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==
-
 
+
<StructureSection load='1x4q' size='340' side='right'caption='[[1x4q]]' scene=''>
-
===Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [https://pdbe.org/1x4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [https://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
-
[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[https://omim.org/entry/601414 601414]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4q_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x4q ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Nucleoprotein|Nucleoprotein]]
+
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
-
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
+
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: He, F.]]
+
[[Category: Large Structures]]
-
[[Category: Inoue, M.]]
+
[[Category: He F]]
-
[[Category: Kigawa, T.]]
+
[[Category: Inoue M]]
-
[[Category: Muto, Y.]]
+
[[Category: Kigawa T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Muto Y]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Shirouzu M]]
-
[[Category: Terada, T.]]
+
[[Category: Terada T]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yokoyama S]]
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Pwi domain]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rna binding protein]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+

Current revision

Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)

PDB ID 1x4q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x4q"
Personal tools