This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1x5d
From Proteopedia
(Difference between revisions)
| (15 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1x5d.gif|left|200px]]<br /><applet load="1x5d" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1x5d" /> | ||
| - | '''The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase A6'''<br /> | ||
| - | == | + | ==The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase A6== |
| - | + | <StructureSection load='1x5d' size='340' side='right'caption='[[1x5d]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1x5d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5D FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5d OCA], [https://pdbe.org/1x5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5d RCSB], [https://www.ebi.ac.uk/pdbsum/1x5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5d ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5d TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDIA6_HUMAN PDIA6_HUMAN] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.<ref>PMID:15466936</ref> <ref>PMID:12204115</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x5d_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x5d ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Inoue M]] | |
| - | [[Category: Inoue | + | [[Category: Kigawa T]] |
| - | [[Category: Kigawa | + | [[Category: Koshiba S]] |
| - | [[Category: Koshiba | + | [[Category: Tochio N]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Tochio | + | |
| - | [[Category: Yokoyama | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
The solution structure of the second thioredoxin-like domain of human Protein disulfide-isomerase A6
| |||||||||||
Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Tochio N | Yokoyama S
